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What is the current state of epi-drugs targeting DNA methylation used against leukemias, and what is their validity in terms of efficacy and safety?

Project by Polygence alum Dheemant (Abhi)

What is the current state of epi-drugs targeting DNA methylation used against leukemias, and what is their validity in terms of efficacy and safety?

Project's result

Research Paper, Symposium Presentation

They started it from zero. Are you ready to level up with us?

Summary

Epigenetic modifications are alterations to the genome that do not change the nucleotide sequence. These changes can alter gene expression, and have emerged as crucial factors in the onset and progression of various cancers, prompting increased research efforts to understand their role in disease pathogenesis. Here, we explore the efficacy and safety of emerging epigenetic treatments, or epi-drugs, as a new avenue for treating various leukemias. Specifically, we examine the role of DNA methylation in regulating gene expression patterns and cellular behavior, evaluate a series of clinical trials performed on the most common epi-drugs for cancer treatment, including 5-Azacytidine and Decitabine, and introduce strategies that may enhance the effectiveness of these agents, including combination therapies and personalized treatment approaches. Furthermore, emerging trends and technologies in epi-drug research are discussed, highlighting the potential for advancements in the field, with a particular focus on DNA methylation-targeting epi-drugs. Further research into epidrugs, epigenetic treatments, and combination therapies holds the potential to substantially reduce the burden on leukemia patients, offering new hope for improved treatment outcomes.

Sabin

Sabin

Polygence mentor

PhD Doctor of Philosophy

Subjects

Medicine, Neuroscience, Biology

Expertise

Neuroscience, Genetics, Genomics, Epigenetics, Biochemistry, Genomics, Cancer biology

Review of mentor

Sabin was very helpful as she allowed me to self-pace my research, and was always willing to be a good critique of my work.

Dheemant (Abhi)

Dheemant (Abhi)

Student

Graduation Year

2024

Project review

Mentor picking and project work were above expectations.