Gene Therapy With CRISPR-Cas9 To Treat Multiple Sclerosis
Project by Polygence alum Emel
This project has been published on Research Archive of Rising Scholars.
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Multiple Sclerosis (MS) is a chronic immune-mediated neurodegenerative disease leading to progressive demyelination and atrophy in the brain. This project aims to first briefly highlight immune mediators of the disease, especially regulatory T cells (Tregs). The project will then discuss biomarkers associated with MS, focusing on those expressed by Tregs. Subsequently, the CRISPR-Cas9 system and how it targets genes for deletion, insertion, or replacement will be described. The final part of the project will discuss different targets and delivery methods for CRISPR-Cas9 therapy for MS.
PhD Doctor of Philosophy candidate
Neuroscience, Biology, Alzheimer's Disease, Multiple Sclerosis, Cell and Molecular Biology, Immunology
Review of mentor
He was amazing. He helped me a lot and guided me throughout the process. He was so friendly as well.
Hello! My name is Emel and I'm a high school graduate. I'm planning to study molecular biology and neuroscience in college to pursue my dream of becoming a scientist one day.
My project expectation was to conduct my own research with my mentor and this expectation of mine was met on Polygence.