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Gene Therapy With CRISPR-Cas9 To Treat Multiple Sclerosis

Project by Polygence alum Emel

Gene Therapy With CRISPR-Cas9 To Treat Multiple Sclerosis

Project's result

This project has been published on Research Archive of Rising Scholars.

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Summary

Multiple Sclerosis (MS) is a chronic immune-mediated neurodegenerative disease leading to progressive demyelination and atrophy in the brain. This project aims to first briefly highlight immune mediators of the disease, especially regulatory T cells (Tregs). The project will then discuss biomarkers associated with MS, focusing on those expressed by Tregs. Subsequently, the CRISPR-Cas9 system and how it targets genes for deletion, insertion, or replacement will be described. The final part of the project will discuss different targets and delivery methods for CRISPR-Cas9 therapy for MS.

Joshua

Joshua

Polygence mentor

PhD Doctor of Philosophy candidate

Subjects

Biology, Neuroscience

Expertise

Neuroscience, Biology, Alzheimer's Disease, Multiple Sclerosis, Cell and Molecular Biology, Immunology

Review of mentor

He was amazing. He helped me a lot and guided me throughout the process. He was so friendly as well.

Emel

Emel

Student

Hello! My name is Emel and I'm a high school graduate. I'm planning to study molecular biology and neuroscience in college to pursue my dream of becoming a scientist one day.

Graduation Year

2022

Project review

My project expectation was to conduct my own research with my mentor and this expectation of mine was met on Polygence.